TRPA 1 channel is a cardiac target of mIGF - 1 / SIRT 1 signaling 1 2 3 4

TRPA1 channel is a cardiac target of mIGF-1/SIRT1 signaling 1 2 3 4 Valerio Pazienza, Cristoforo Pomara, Francesco Cappello, Raffaele 5 Calogero, Matteo Carrara, Gianluigi Mazzoccoli†, Manlio Vinciguerra† 6 7 8 Department of Medical Sciences, Division of Gastroenterology, IRCCS Scientific 9 Institute “Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Italy; Department 10 of Anatomy, University of Malta, Msida, Malta; Department of Forensic Pathology, 11 University of Foggia, Foggia, Italy; Department of Experimental Medicine and 12 Clinical Neuroscience, Section of Human Anatomy, University of Palermo, Palermo, 13 Italy; Euro-Mediterranean Institute of Science and Technology, Palermo, Italy; 14 Molecular Biotechnology Center, University of Turin, Italy; Department of Medical 15 Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific 16 Institute “Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Italy; Division of 17 Medicine, University College London (UCL), United Kingdom. 18 19 20 21 22 23 Running Head: TRPA1 and cardiac mIGF-1/SIRT1 signaling 24 25 26 *,† These authors contributed equally to this article 27 28 29 30 31 #Address for correspondence: Manlio Vinciguerra, PhD 32 University College London (UCL) Institute for 33 Liver and Digestive Health 34 UCL Medical School Royal Free Campus 35 London NW3 2PF 36 United Kingdom 37 Tel: 0044 (0) 20 74332874 38 Fax: 0044 (0) 20 7433 2852 39 E-mail: [email protected] 40 41 42 43 44 45 46 47 48 49 Articles in PresS. Am J Physiol Heart Circ Physiol (August 8, 2014). doi:10.1152/ajpheart.00150.2014